| 主权项 |
1. A compound having structural Formula I: or a pharmaceutically acceptable salt thereof wherein: —X—R—(CH2)n2- is and where R represents a 4-6-membered heterocyclic ring of the following structure: with the proviso that R—I is not a para-substituted 6-membered ring; a is CH2—, —CH2CH2—, —CH2CH2CH2—, —CH2OCH2— or absent; wherein the CH2— is optionally substituted with 1-2 of —F, and wherein the —CH2CH2—, —CH2CH2CH2—, or —CH2OCH2— is optionally substituted with 1-3 of —F; and wherein a forms a bridge between two non-adjacent carbons; R5 is —H, —F with the proviso that —F is not attached to a carbon also bonded to nitrogen, —CH3, —CF3, —CHF2, —CH2F, or —CH2OH, or R5 represents di-substitution on a single carbon with two of —F with the proviso that the two —F are not attached to a carbon also bonded to nitrogen, or two of —CH3; R6 and R7 are individually either H, C1-3 alkyl optionally substituted with 1-3 of —F, or R6 and R7 can be taken together with the carbon atom to which they are attached to form C3 cycloalkyl optionally substituted with 1-3 of —F; R8 is H, —F, —CH3, —CF3, —CHF2, —CH2F, or —CH2OH, or phenyl optionally substituted with 1-3 of —F or C1-3 alkyl; n1 and n2 can be individually either 0 or 1; Z1 is: one of W1 and W2 is N and the other is CH; R1 and R2 are each independently —H, —F, —Cl, —Br, cyclopropyl, —C1-3alkyl optionally substituted with 1-3 of —F, or —OC1-3alkyl optionally substituted with 1-3 of —F; one of R3a and R3b is —CN, tetrazolyl, or S(O)2C1-3alkyl and the other is —H, —F, —Cl, —Br, —S—CH3, —NH—CH3, —O-cyclopropyl, —C1-3alkyl optionally substituted with 1-3 of —F, or —OC1-3 alkyl optionally substituted with 1-3 of —F; one of R4a and R4b is —CN, tetrazolyl, or S(O)2C1-3alkyl and the other is —H, —F, —Cl, —Br, —S—CH3, —NH—CH3, —O-cyclopropyl, —C1-3alkyl optionally substituted with 1-3 of —F, or —OC1-3 alkyl optionally substituted with 1-3 of —F; Ra, Raa, Rb and Rbb are each independently —H, —F, Cl, —C1-3alkyl optionally substituted with 1 to 3 of —F, or —OC1-3alkyl optionally substituted with 1 to 3 of —F; Re and Rd are each independently H, —F, Cl, —C1-3 alkyl optionally substituted with 1 to 3 of —F, or —OC1-3 alkyl optionally substituted with 1 to 3 of —F; X is absent or C1 alkyl having 2 substituents independently H, or —C1-3 alkyl optionally substituted with 1 to 3 of —F, wherein two —C1-3 alkyl substituents can be taken together with the C1 alkyl to which they are attached to form a C3-6 cycloalkyl; and one of Y1 or Y2 is CH(OH)—; and the other is CH(OH)—; S(O)2—; S(O)2CH2—; —CH2— wherein —CH2— is optionally substituted with —C1-3 alkyl optionally substituted with OH, —OC1-3alkyl, or −1-3 of —F, or absent; provided that where Y1 or Y2 is S(O)2— or S(O)2CH2—, then the adjacent n1 or n2, respectively, is 0; and provided further that where Y1 or Y2 is CH(OH)—, then the adjacent n1 or n2, respectively, is 1. |
