COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM

摘要

Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

主权项

1. A compound having the structure of Formula (I):wherein:
L1 is O, S, or NR11 wherein R11 is H, C1-C6alkyl, or C2-C6alkenyl; L2 is —NH—C(═O)—, or —C(═O)NH—; R1 is aryl or heteroaryl; wherein aryl or heteroaryl is optionally substituted with at least one R3 or forms a bicyclic system; R2 is aryl or heteroaryl; wherein aryl or heteroaryl is optionally substituted with at least one R3; R3 is independently selected from H, F, Cl, Br, I, —CN, —NO2, —OH, —CF3, —OR5, C6alkyl, C3-C8cycloalkyl, C1-C6heteroalkyl, C1-C6haloalkyl, C2-C8heterocycloalkyl, optionally substituted aryl, optionally substituted O-aryl, optionally substituted heteroaryl, —NHS(═O)2R4, —S(═O)2N(R5)2, —N(R5)S(═O)2N(R5)2, —C(═O)CF3, —C(═O)NHS(═O)2R4, —S(═O)2NHC(═O)R4, —N(R5)2, —N(R5)C(═O)R5, —N(R5)C(═O)N(R5)2, —N(R5)C(═O)OR4, —CO2R5, —C(═O)R5, —OC(═O)R4, —OC(═O)N(R5)2, —CON(R5)2, —SR5, —S(═O)R4, and —S(—O)2R4; n is an integer selected from 0 to 4; each R4 is independently selected from C1-C6alkyl, C1-C6haloalkyl, C3-C8cycloalkyl, phenyl, and benzyl; each R5 is independently selected from H, C1-C6alkyl, C1-C6haloalkyl, C3-C8cycloalkyl, phenyl, and benzyl; or a pharmaceutically acceptable salt, pharmaceutically acceptable solvate, or pharmaceutically acceptable prodrug thereof.