PREPARATION METHOD OF AN IMPLANT COMPRISING DRUG DELIVERY LAYER AND IMPLANT COMPOSITION FOR LIVING DONOR TRANSPLANTATION COMPRISING THE SAME

摘要

The present invention relates to a preparation method of implant comprising drug delivery layer and implant composition for living donor transplantation comprising the same, and more specifically, a preparation method of implant comprising drug delivery layer comprising preparing chitosan-bioactive glass composite solution; preparing drug-containing complex coating composition by adding drug in the chitosan-bioactive glass composite solution; and preparing drug delivery layer by electrophoresis of the complex coating composition on the surface of implant, and implant composition for living donor transplantation comprising the same. The implant composition according to the present invention is able to deliver the drug, and therefore to prevent inflammation, which may occur after the surgery, as well as to promote recovery depending on the type of drugs contained. Thus, a preparation method of implant comprising drug delivery layer and implant composition for living donor transplantation comprising the same according to the present invention can be usefully applied to the bone transplantation field and bone transplant material.

主权项

1. A method for preparation of an implant comprising a drug delivery layer comprising
1) preparing a chitosan-bioactive glass composite solution by dispersing chitosan solution in solvent and adding surface aminated bioactive glass nanoparticles; 2) preparing a drug-containing complex coating composition by adding a drug to the chitosan-bioactive glass composite solution; and 3) preparing a drug delivery layer by electrophoretic deposition of the complex coating composition on the surface of the implant.