| 发明名称 |
Stabilized polymeric thiol reagents |
| 摘要 |
Disclosed are water soluble polymeric conjugates comprising the structure POLY-[Y—S—S-A]x, where POLY is a water soluble polymer; Y is a hydrocarbon-based spacer group, x is 1 to 2, S—S is a disulfide group attached to an sp3 hybridized carbon of Y; and A is a covalently linked residue of a pharmacologically active molecule. Preferably, the water soluble polymer is a PEG polymer. Also disclosed are polymeric reagents useful to prepare such conjugates, and methods of their formation and use. |
| 申请公布号 |
US8765883(B2) |
申请公布日期 |
2014.07.01 |
| 申请号 |
US201313921889 |
申请日期 |
2013.06.19 |
| 申请人 |
Nektar Therapeutics |
发明人 |
Kozlowski Antoni;McManus Samuel P. |
| 分类号 |
C08G75/00;C08F283/00;C08L81/00;A61K31/415 |
主分类号 |
C08G75/00 |
| 代理机构 |
|
代理人 |
Wilson Mark A. |
| 主权项 |
1. A polymer conjugate comprising the structure:
POLY-[Y—S—S-A]x wherein:
POLY is a water soluble polymer which is a polyethylene glycol; Y is a divalent linking group consisting of a saturated hydrocarbon backbone which is 4 to 6 carbon atoms in length and has substitutents selected from the hydrogen and methyl; S—S is a disulfide group attached to an sp3 hybridized carbon of Y; and A is a covalently linked residue of a pharmacologically active molecule; and x is 1 or 2. |
| 地址 |
San Francisco CA US |
