| 发明名称 |
FGF21 conjugates and anti-diabetic uses thereof |
| 摘要 |
The present invention provides a FGF21 molecule covalently attached to the combining site of an antibody via a linker, wherein the linker is covalently attached to the side chain of a linking residue within FGF21. Various uses of the compounds are provided, including methods to prevent or treat diabetes or diabetes-related conditions. |
| 申请公布号 |
US8722622(B2) |
申请公布日期 |
2014.05.13 |
| 申请号 |
US201113289533 |
申请日期 |
2011.11.04 |
| 申请人 |
DAS TAPAN KANTI;HODGE TAMARA SHAFER;ISHINO TETSUYA;LEVIN NANCY JANE;PALANKI MOORTHY SITHARAMAIAH SURIYANARAYANA;PARSONS ERIN KRISTEN;VIOLAND BERNARD NORMAN;COVX TECHNOLOGIES IRELAND, LIMITED;PFIZER INC. |
发明人 |
DAS TAPAN KANTI;HODGE TAMARA SHAFER;ISHINO TETSUYA;LEVIN NANCY JANE;PALANKI MOORTHY SITHARAMAIAH SURIYANARAYANA;PARSONS ERIN KRISTEN;VIOLAND BERNARD NORMAN |
| 分类号 |
A61K38/18;A61K39/395 |
主分类号 |
A61K38/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
