SODIUM CHANNEL BLOCKERS, PREPARATION THEREOF AND USE THEREOF

摘要

The present invention relates to a compound having a blocking effect for sodium ion channel, particularly for Nav1.7, a preparation method thereof, and a use thereof. The compound represented by Chemical formula 1, or a pharmaceutically acceptable salt, a hydrate, a solvate, or an isomer thereof, of the present invention can be used for preventing or treating pains such as acute pain, chronic pain, pathological nerve pain, postoperative pain, migraine, joint pain, neuropathy, nerve damage, diabetic neuropathy, neuropathic disorders, epilepsy, arrhythmia, paramyotonia, ataxia, multiple sclerosis, irritable bowel syndrome, urinary incontinence, visceral pain, depression, erythermelalgia, and paroxysmal extreme pain disorder (PEPD).