发明名称 |
Large-scale production of soluble hyaluronidase |
摘要 |
<p>Provided are methods for preparing large-scale preparations of soluble hyaluronidases. The methods employ cells that contain a plurality of active copies of nucleic acid encoding the soluble hyaluronidase and a plurality of feedings and temperature changes, whereby the encoded soluble hyaluronidase is secreted into the cell culture medium.</p> |
申请公布号 |
EP2674487(A2) |
申请公布日期 |
2013.12.18 |
申请号 |
EP20130184202 |
申请日期 |
2009.03.06 |
申请人 |
HALOZYME, INC. |
发明人 |
BAKER, DAVID;BOOKBINDER, LOUIS |
分类号 |
C12N9/26 |
主分类号 |
C12N9/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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