METHODS AND COMPOSITIONS FOR TREATING AMYLOID DEPOSITS
摘要
<p>The present disclosure provides methods of delivering a protective ApoE isoform to the central nervous system of a mammal, comprising administering to the cerebrospinal fluid (CSF) of the mammal an rAAV particle comprising an AAV capsid protein and a vector comprising a nucleic acid encoding the protective ApoE isoform inserted between a pair of AAV inverted terminal repeats in a manner effective to infect ependymal cells in the non-rodent mammal such that the ependymal cells secrete the ApoE into the CSF of the mammal.</p>
申请公布号
WO2013172964(A1)
申请公布日期
2013.11.21
申请号
WO2013US31725
申请日期
2013.03.14
申请人
UNIVERSITY OF IOWA RESEARCH FOUNDATION;THE GENERAL HOSPITAL CORPORATION;DAVIDSON, BEVERLY, L.;HYMAN, BRADLEY, T.