NOVEL INDOLE OR INDAZOLE DERIVATIVE OR SALT THEREOF

摘要

The the present invention relates to provision of a novel indazole compound which is capable of inhibiting HSP90 and shows a cytostatic effect on cancer cells. The present invention also relates to provision of a drug useful for preventing and/or treating, on the basis of an HSP90 inhibitory effect, a disease in which HSP90 participates, in particular, cancer. A compound represented by the general formula (I) or a salt thereof:
wherein
X represents CH or N;
any one or two of Y 1 , Y 2 , Y 3 , and Y 4 represent C-R 3 or N, and the others represent CH;
A and B are the same or different and represent an optionally substituted monocyclic unsaturated heterocyclic group having 1 to 4 heteroatoms selected from N, S, and O;
R 1 represents a hydrogen atom, an optionally substituted alkyl group having 1 to 6 carbon atoms etc.;
R 2 represents a hydrogen atom, a halogen atom etc.;
R 3 represents a hydrogen atom, a halogen atom etc.;
R 4 and R 5 are the same or different and represent a hydroxyl group etc.;
R 6 and R 7 are the same or different and represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms etc.; and
R 8 represents an optionally substituted cycloalkyl group having 3 to 7 carbon atoms etc.