发明名称 |
Humanized antibodies against the beta-amyloyd peptide |
摘要 |
<p>The invention discloses an isolated antibody that selectively binds to the C-terminal part of Abeta and is humanized or fully human. The antibody of the invention is capable of preventing oligomerisation of Abeta. Furthermore, a method of diagnosis comprising the steps of: (i) Labelling an antibody; (ii) Administering an effective dose of said antibody intranasally or systemically to a subject; and (iii) Detecting the concentration and/or presence of the labelled antibody in body parts of the subject is disclosed.</p> |
申请公布号 |
AU2008299516(B2) |
申请公布日期 |
2013.09.12 |
申请号 |
AU20080299516 |
申请日期 |
2008.09.15 |
申请人 |
DELENEX THERAPEUTICS AG;UNIVERSITY OF ZURICH |
发明人 |
AUF DER MAUR, ADRIAN;NITSCH, ROGER;CATTEPOEL, SUSANN;EWERT, STEFAN |
分类号 |
C07K16/18;A61K39/395;A61P25/28;G01N33/53 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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