发明名称 |
FUSED DIHYDROPYRIDO [2,3 -B] PYRAZINES AS IP RECEPTOR AGONISTS FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION (PAH) AND RELATED DISORDERS |
摘要 |
<p>The present invention provides heterocyclic derivatives which activate the IP receptor, processes for preparing them, pharmaceutical compositions comprising said derivatives and uses thereof. Activating the IP receptor signaling pathway is useful to treat many forms of PAH, pulmonary fibrosis and exert beneficial effects in fibrotic conditions of various organs in animal models and in patients. Formula (I):</p> |
申请公布号 |
WO2013105061(A1) |
申请公布日期 |
2013.07.18 |
申请号 |
WO2013IB50277 |
申请日期 |
2013.01.11 |
申请人 |
NOVARTIS AG |
发明人 |
LEBLANC, CATHERINE;MCKEOWN, STEPHEN CARL;CHARLTON, STEVEN JOHN;BHALAY, GURDIP;HEALY, MARK PATRICK |
分类号 |
C07D471/04;A61K31/4985;A61P9/00;A61P11/00 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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