摘要 |
Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminium salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form. |
申请人 |
NOVARTIS AG;IRM LLC |
发明人 |
SINGH, MANMOHAN;SKIBINSKI, DAVID, A.G.;WU, TOM, YAO-HSIANG;LI, YONGKAI;CORTEZ, ALEX;ZHANG, XIAOYUE;ZOU, YEFEN;HOFFMAN, TIMOTHY, Z.;PAN, JIANFENG;YUE, KATHY |