<p>A PGC-1 expression-modulating device (1) according to the present invention includes an ultrasonic wave transmitting section (14) that irradiates a subject living body with ultrasonic waves. This configuration modulates PGC-1 expression in a living body and promotes angiogenesis in which VEGF is involved. This enables promoting angiogenesis in a living body and treating ischemic disease without an excessive burden on a patient.</p>
