发明名称 |
Aldehyde-Tagged Immunoglobulin Polypeptides and Methods of Use Thereof |
摘要 |
The present disclosure provides aldehyde-tagged immunoglobulin (Ig) polypeptides that can be converted by a formylglycine-generating enzyme to produce a 2-formylglycine (FGly)-modified Ig polypeptide. An FGly-modified Ig polypeptide can be covalently and site-specifically bound to a moiety of interest to provide an Ig conjugate. The disclosure also encompasses methods of production of such aldehyde-tagged Ig polypeptides, FGly-modified Ig polypeptides, and Ig conjugates, as well as methods of use of same. |
申请公布号 |
US2012183566(A1) |
申请公布日期 |
2012.07.19 |
申请号 |
US201213350676 |
申请日期 |
2012.01.13 |
申请人 |
BARFIELD ROBYN M.;BREIDENBACH MARK ALAN;DEHART GREGORY W.;RABUKA DAVID |
发明人 |
BARFIELD ROBYN M.;BREIDENBACH MARK ALAN;DEHART GREGORY W.;RABUKA DAVID |
分类号 |
A61K39/395;A61P35/00;C07K1/107;C07K16/00;C07K16/08;C07K16/30;C12N15/13;C12N15/63;C40B40/02;C40B40/10 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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