发明名称 |
Compositions and methods with enhanced therapeutic activity |
摘要 |
Novel quinone and catechol compositions, compositions containing prodrugs of quinone and catechol compositions, and methods of use for the treatment of solid tumor cancers and other vascular proliferative disorders. The disclosure particularly relates to the discovery of dual activity agents capable of generating both a vascular targeting effect and direct tumor cell cytotoxicity in order to achieve an enhanced anti-tumor response in a patient. |
申请公布号 |
US8198302(B2) |
申请公布日期 |
2012.06.12 |
申请号 |
US20040790662 |
申请日期 |
2004.03.01 |
申请人 |
CHAPLIN DAVID J.;EDVARDSEN KLAUS;PINNEY KEVIN G.;PREZIOSO JOSEPH ANTHONY;WOOD MARK;OXIGENE, INC.;BAYLOR UNIVERSITY |
发明人 |
CHAPLIN DAVID J.;EDVARDSEN KLAUS;PINNEY KEVIN G.;PREZIOSO JOSEPH ANTHONY;WOOD MARK |
分类号 |
A61K31/445;A01N31/14;A61K;A61K31/075;A61K31/16;A61K31/36;A61K31/66;C07C9/02;C07C41/00;C07C43/02;C07C43/20 |
主分类号 |
A61K31/445 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|