发明名称 |
Peptide nucleic acids conjugated with multi-amine linkers and nucleic acid detecting device using the same |
摘要 |
The present invention relates to a peptide nucleic acid (PNA) conjugated with multi-amine linkers, and a method to prepare the same and utilization thereof. More specifically, the method is characterized by conjugating monomers having multi-amine functionality sequentially at a PNA terminal, and effectively immobilizing the PNA conjugated with multi-amine linkers on a solid surface. A PNA array prepared using the PNA conjugated with multi-amine linkers exhibits improved sensitivity and specificity of signals for detecting target nucleic acids as compared to a PNA array using PNA probes having only one amine group. The PNA conjugated with multi-amine linkers can be utilized in nucleic acid detecting devices or kits for gene diagnosis such as PNA microarrays, PNA chips, PNA field-effect transistors and impedance detectors.
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申请公布号 |
US8133985(B2) |
申请公布日期 |
2012.03.13 |
申请号 |
US20070300235 |
申请日期 |
2007.12.14 |
申请人 |
LEE HYUNIL;PARK HEE KYUNG;UM BONG HO;KIM SERKA;CHOI JAE JIN;MIN JUNG HYUN;KIM HYE YEON;PANAGENE INC. |
发明人 |
LEE HYUNIL;PARK HEE KYUNG;UM BONG HO;KIM SERKA;CHOI JAE JIN;MIN JUNG HYUN;KIM HYE YEON |
分类号 |
C07K2/00;C07K1/00;C40B40/06;C40B80/00 |
主分类号 |
C07K2/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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