发明名称 |
INHIBITORS OF STAT3 |
摘要 |
<p>Disclosed herein are compounds derived from a chemical structure according to the formula (I) wherein X comprises oxygen or sulfur, R1 comprises a phenyl or naphthyl group, R2 comprises an amide group and R3 comprises a phosphate group. The disclosed compounds demonstrate inhibitory activity against STAT3, a protein found in certain tumor tissues and which promotes cellular overproliferation and resistance to apoptosis. The invention includes compositions containing the disclosed compounds, as well as methods of treatment therewith.</p> |
申请公布号 |
EP2346829(A1) |
申请公布日期 |
2011.07.27 |
申请号 |
EP20090815184 |
申请日期 |
2009.09.17 |
申请人 |
UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. |
发明人 |
TURKSON, JAMES;HAMILTON, ANDREW, D. |
分类号 |
C07D215/00;A61K31/421;A61K31/426;A61K31/661;A61P35/00;C07D263/34;C07D277/56;C07F9/12;C07F9/653;C07F9/6539 |
主分类号 |
C07D215/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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