发明名称 |
PROCESS FOR PRODUCING CILOSTAZOL |
摘要 |
<p>The present invention provides a process for producing cilostazol ÄIÜ in a high yield and a high purity, by reacting a carbostyril derivative ÄIIÜ with a tetrazole derivative ÄIIIÜ in the presence of an inorganic basic compound in a solvent of water, wherein water is used in an amount of 3 to 7-fold weight to that of the carbostyril derivative ÄIIÜ and the inorganic basic compound is used in an amount of 1 to 6 mol per mol of the carbostyril derivative ÄIIÜ. The process of the present invention is the improved and environment-friendly process for producing cilostazol being useful for pharmaceuticals. <CHEM></p> |
申请公布号 |
SI1489080(T1) |
申请公布日期 |
2011.05.31 |
申请号 |
SI20030031965T |
申请日期 |
2003.09.09 |
申请人 |
OTSUKA PHARMACEUTICAL CO., LTD. |
发明人 |
YAMAMOTO AKIHIRO;FUKUYAMA NORIHIRO;OKAICHI YOSHIHIKO;YAMADA YASUHIRO;MIYAMOTO HISASHI;TOMINAGA MICHIAKI |
分类号 |
C07D401/12;C07D403/12 |
主分类号 |
C07D401/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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