| 摘要 |
<p>The invention relates to cell therapy for the treatment of HIV infection in humans. It provides a composition of genetically modified human cells for introduction into the body of a person infected with HIV, to reduce the person's viral load and to provide and reconstitute T-cells that are resistant to HIV infection. The composition comprises allogeneic or autologous human CD4+ T-cells, allogeneic or autologous human hematopoietic stem cells (HSCs), and allogeneic or autologous human mesenchymal stem cells (MSCs). Each cell comprises at least one heterologous anti-HIV sequence that inhibits HIV from infecting the cells or from replicating in the cells and at least one heterologous fate-controlling sequence. The invention also provides lentiviral vectors for making the cells, plasmids and producer cells for making the vectors, and methods for making the genetically modified cells.</p> |
