PURPOSE: An injection composition for anti-cancer which containing docetaxel as an active ingredient is provided ensure bioavailability same as a conventional injection product and low hemolysis. CONSTITUTION: An injection composition contains docetaxel as an active ingredient, glycofurol(tetrahydrofurfuryl alcohol polyethyleneglycolether) or DMA(dimethylaceteamide) as a solubilizing agent, and solutol, acepol, or poroxamer as a surfactant. The weight ratio between solubilizing agent and surfactant is 1:0.5-6. The pH concentration of the injection composition is adjusted at pH 4-6.
申请公布号
KR20100018741(A)
申请公布日期
2010.02.18
申请号
KR20080077386
申请日期
2008.08.07
申请人
SHIN POONG PHARMACEUTICAL CO., LTD.;THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC)
发明人
HWANG, SUNG JOO;PARK, HEE JUN;LEE, YOUNG JOO;KIM, MIN SOO;KIM, JEONG SOO;KIM, KEE WON;NOH, JEONG RYUL;NAM, DAE YOUNG