ARIPIPRAZOLE COMPLEX FORMULATION AND METHOD

摘要

AN ARIPIPRAZOLE FORMULATION IS PROVIDED WHICH INCLUDES THE ANTIPSYCHOTIC AGENT ARIPIPRAZOLE IN THE FORM OF AN INCLUSION COMPLEX IN A -CYCLODEXTRIN, PREFEREABLY, SULFOBUTYL ETHER -CYCLODEXTRIN (SBECD), WHICH IN THE FORM OF AN INJECTABLE PRODUCES REVERSIBLE GENERALLY MINIMAL TO MILD IRRITATION AT THE INTRAMUSCULAR INJECTION SITE. A METHOD FOR MINIMIZING OR REDUCING IRRITATION CAUSED BY ARIPIPRAZOLE AT AN INTRAMUSCULAR INJECTION SITE AND A METHOD FOR TREATING SCHIZOPHRENIA EMPLOYING THE ABOVE FORMULATION ARE ALSO PROVIDED.