发明名称 |
In vivo temporal control of activatable matrix-degrading enzymes |
摘要 |
Methods and combinations are provided for controlling the duration of action, in vivo, of matrix-degrading enzymes. The methods and combinations permit temporary in-vivo activation of matrix-degrading enzymes upon administration to the extra cellular matrix (or "ECM"). Matrix-degrading enzymes having a controlled duration of action can be used to treat ECM-mediated diseases or disorders characterized by increased deposition or accumulation of one or more ECM components.
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申请公布号 |
US2010003237(A1) |
申请公布日期 |
2010.01.07 |
申请号 |
US20090381063 |
申请日期 |
2009.03.06 |
申请人 |
KELLER GILBERT;FROST GREGORY I |
发明人 |
KELLER GILBERT;FROST GREGORY I. |
分类号 |
A61K38/46;A61K38/47;A61K38/48;A61P17/02 |
主分类号 |
A61K38/46 |
代理机构 |
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代理人 |
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地址 |
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