TRANSDERMAL PATCH CONTAINING FENTANYL OR SALT THEREOF

摘要

Provided is a patch containing fentanyl or a derivative thereof which causes no lowering in the stickiness to the skin, has a high drug-stability, can inhibit the time-dependent deposition of fentanyl crystals, yet little irritates the skin and shows an extremely high skin permeability of fentanyl. A patch containing fentanyl or a derivative thereof consisting of a support, a pressure-sensitive adhesive layer containing fentanyl or a derivative thereof and a release liner, wherein the pressure-sensitive adhesive layer containing fentanyl or a derivative thereof contains 0.01 to 0.5% by mass of an ascorbate such as an L-ascorbate palmitate.  A patch containing fentanyl or a derivative thereof which further contains a hindered phenol-type antioxidant in an amount sufficient for the inhibition of the deposition of fentanyl or a salt of the same.