发明名称 |
Morpholinyl-urea derivatives for use in the treatment of inflammatory diseases |
摘要 |
Compounds of formula (I): wherein: R1 represents substituted or unsubstituted heteroaryl; Y represents -(CRnaRnb)n-; Rna and Rnb are each independently hydrogen or C1-6alkyl; n is an integer from 0 to 5; R2 represents unsubstituted or substituted aryl or unsubstituted or substituted heteroaryl; R3 and R4 each independently represent hydrogen or C1-6-alkyl; R7 represents hydrogen or C1-6alkyl; R8 represents hydrogen or C1-6alkyl; and salts and solvates thereof; are CCR3 antagonists and are thus indicated to be useful in therapy.
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申请公布号 |
US7622464(B2) |
申请公布日期 |
2009.11.24 |
申请号 |
US20050509162 |
申请日期 |
2005.06.10 |
申请人 |
GLAXO GROUP LIMITED |
发明人 |
ANCLIFF RACHAEL ANN;COOK CAROLINE MARY;ELDRED COLIN DAVID;GORE PAUL MARTIN;HARRISON LEE ANDREW;HAYES MARTIN ALISTAIR;HODGSON SIMON TEANBY;JUDD DUNCAN BRUCE;KEELING SUZANNE ELAINE;LEWELL XIAO QING;MILLS GAIL;ROBERTSON GRAEME MICHAEL;SWANSON STEPHEN;WALKER ANDREW JOHN;WILKINSON MARK |
分类号 |
A61K31/535;C07D413/12;A61K31/5377;A61P11/02;A61P11/06;A61P29/00;A61P43/00;C07D231/12;C07D253/06;C07D257/04;C07D271/06;C07D307/34;C07D333/38;C07D413/14;C07D417/12 |
主分类号 |
A61K31/535 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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