The invention provides corticosteroids that are chemically modified by covalent attachment of a water soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the corticosteroid not attached to the water soluble oligomer.
申请公布号
WO2009045539(A3)
申请公布日期
2009.11.19
申请号
WO2008US11523
申请日期
2008.10.03
申请人
NEKTAR THERAPEUTICS;ZHANG, WEN;RIGGS-SAUTHIER, JENNIFER;HARRIS, J., MILTON;BENTLEY, MICHAEL, D.
发明人
ZHANG, WEN;RIGGS-SAUTHIER, JENNIFER;HARRIS, J., MILTON;BENTLEY, MICHAEL, D.