| 摘要 |
(-)-EGCG, the most abundant catechin, was found to be chemopreventive and anticancer agent. However, (-)-EGCG has at least one limitation: it gives poor bioavailability. This invention provides compounds of generally formula 10, wherein R1 is selected from the group of -H and C1 to C6 acyl group; R2, R3, and R4 are each independently selected from the group of -H, -OH, and C1 to C6 acyloxyl group; and at least one of R2, R3, or R4 is -H. The derivatives of (-)-EGCG that is at least as potent as (-)-EGCG. The carboxylate protected forms of (-)-EGCG and its derivatives are found to be more stable than the unprotected forms, which can be used as proteasome inhibitors to reduce tumor cell growth.
|
