SUSTAINED RELEASE PREPARATION CONTAINING METAL SALT OF A PEPTIDE

摘要

A sustained-release preparation containing a water-insoluble or slightly wat er- soluble polyvalent metal salt of a water-soluble peptide type of physiologically active substance except for an endothelin antagonist and a biodegradable polymer. The present invention is a sustained-release preparation that is highly efficient in incorporating a water-soluble peptide type of physiologically active substance except for an endothelin antagonist and suppresses initital burst of the water- soluble peptide type of physiologically active substance except for an endothelin antagonist. The sustained-release preparation of the present invention is capable of releasing the water-soluble peptide type of physiologically active substance except for an endothelin antagonist while retaining its bioactivity after administration in vivo. Furthermore, the water-soluble peptide type of physiologically active substance except fo r an endothelin antagonist in the sustained-release preparation is kept stable for a long period of time, with little loss of bioactivity.