发明名称 |
METHODS OF SCREENING FOR COMPOUNDS HAVING ANTI-INFLAMMATORY ACTIVITY |
摘要 |
A method screens compounds out of the group consisting of proteins, peptides, peptidomimetics, antibodies and small organic molecules that increase the activity of the protein Rac1 by virtue of their binding to the extracellular portion of this protein. The method includes the steps of: contacting a confluent layer of cultured endothelial cells with at least one of test compounds, lysing the endothelial cells with a lysation buffer, and measuring the amount of Rac1 activity.
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申请公布号 |
US2009081192(A1) |
申请公布日期 |
2009.03.26 |
申请号 |
US20070860488 |
申请日期 |
2007.09.24 |
申请人 |
FIBREX MEDICAL RESEARCH & DEVELOPMENT GMBH |
发明人 |
PETZELBAUER PETER;HENNING RAINER;REINGRUBER SONJA;PASTEINER WALTRAUD;GROGER MARION |
分类号 |
C12Q1/34;A61K38/02;A61K39/395;A61P9/00;C12Q1/00;C12Q1/48 |
主分类号 |
C12Q1/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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