发明名称 |
PHENYL AND PYRIDINYL-1,2,4-OXADIAZOLONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS |
摘要 |
The present invention comprises phenyl and pyridinyl 1,2,4-oxadiazolone compounds their physiologically acceptable salts and physiologically functional derivatives that exhibit peroxisome proliferator activator receptor (PPAR) delta agonist activity. Also described and claimed are processes for their preparation and their use as pharmaceuticals. These are compounds of formula I, in which the R-group substituents are defined herein. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved and de-myelinating and other neurodegenerative disorders of the central and peripheral nervous system.
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申请公布号 |
US2008287409(A1) |
申请公布日期 |
2008.11.20 |
申请号 |
US20080055793 |
申请日期 |
2008.03.26 |
申请人 |
SANOFI-AVENTIS |
发明人 |
BERNARDELLI PATRICK;KEIL STEFANIE;URMANN MATTHIAS;MATTER HANS;WENDLER WOLFGANG;GLIEN MAIKE;CHANDROSS KAREN;LEE LAN;TERRIER CORINNE;MINOUX HERVE |
分类号 |
A61K31/427;A61K31/454;A61K31/5377;A61P3/00;A61P3/10;C07D413/14;C07D417/12;C07D417/14 |
主分类号 |
A61K31/427 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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