发明名称 |
PROCESS FOR PRODUCTION OF LIPID A ANALOGUE |
摘要 |
<p>Discloses is a process for producing ±-D-glucopyranose, 3-O-decyl-2-deoxy-6-O-[2-deoxy-3-O-[(3R)-3-methoxydecyl]-6-O-methyl-2-[(11Z)-1-oxo-11-octadecenyl]amino]-4-O-phosphono-²-D-glucopyranosyl]-2-[(1,3-dioxotetradecyl)amino]- or 1-(dihydrogen phosphate) tetrasodium salt which is useful as an active ingredient of a pharmaceutical or an intermediate for the synthesis thereof, which is environment-friendly and excellent in safety, operationality and reproducibility. A process for producing a compound represented by the formula (I) comprising the steps of reacting a compound represented by the formula (VIII) with a palladium catalyst in the presence of a nucleopholic agent and treating the product with a sodium source.</p> |
申请公布号 |
IL189801(D0) |
申请公布日期 |
2008.11.03 |
申请号 |
IL20080189801 |
申请日期 |
2008.02.26 |
申请人 |
EISAI R& D MANAGEMENT CO., LTD.;TAGAMI, KATSUYA;SATO, KEIZO;MATSUO, KIMIHIRO;ABE, TAICHI;HAGA, TOYOKAZU |
发明人 |
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分类号 |
C07H |
主分类号 |
C07H |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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