PRION PROTEIN DETECTION

摘要

A waveguide device comprises a multimode waveguide having a surface-bearing patterned reflective coating defining a reflectively coated region and an optically exposed region on the surface, wherein one or more first antibodies are covalently bonded to or non-covalently immobilized on the optically exposed region, and wherein the one or more first antibodies selectively binds a prion protein. Use of said device to detect prions.