摘要 |
FIELD: organic chemistry, vitamins, medicine. ^ SUBSTANCE: invention relates to analogues of vitamin D of the general formula (I): wherein R1 and R2 mean halogen atom, (C1-C6)-hydrocarbon radical possibly substituted with 1, 2 -OH groups, 1, 2 fluorine (F) atoms, or R1 and R in common means (C3-C6)-carbocycle, or R1 and R2 in common mean a direct bond, or R1 and R2 in common mean hydrogen atom (H); R3 means H or (C1-C3)-hydrocarbon radical; X means (E)-ethylene, (Z)-ethylene, ethynylene or a bond; Y and Z mean H, -CH3; A means -OH, F or H; B means -CH2- or H2 under condition that compound of the formula (I) doesn't mean 3(S)-hydroxy-9,10-secocholesta-5(Z),7(E),10(19),22(E),24-pentaene. Compounds elicit strong suppression effect on secretion of parathyroid hormone and useful in treatment of secondary hyperparathyroiditis possibly associated with renal insufficiency. ^ EFFECT: valuable medicinal properties of vitamin D analogues. ^ 19 cl, 2 tbl, 36 ex |