GENETIC POLYMORPHISMS ASSOCIATED WITH MYOCARDIAL INFARCTION AND USES THEREOF

摘要

A single nucleotide polymorphism(SNP) associated with myocardial infarction in a Korean population is provided to predict the incidence, probability of, and genetic susceptibility to myocardial infarction in accordance with environmental and habitual factors. A polynucleotide for identifying a subject having modified risk of myocardial infarction outbreak is characterized in that it is a polynucleotide or a complimentary polynucleotide thereof consisting of 8-70 consecutive nucleotides including each SNP position nucleotide in a polynucleotide selected from the group consisting of SEQ ID : NOs. 3, 5-8, 10, 11, 13-17, and 22-25, the position of the each SNP is 62nd of the SEQ ID : NO. 3, 77th of the SEQ ID : NO. 6 and 101st of the other remaining SEQ ID : NOs., and the nucleotide of the each SNP position is a nucleotide of an allele A or a described in a table 3. A polypeptide used for identifying a subject having modified risk of myocardial infarction outbreak is encoded by the polynucleotide. An antibody is specifically coupled to the polypeptide. A microarray detects an SNP used for identifying a subject having modified risk of myocardial infarction outbreak. A method for detecting the SNP in a nucleic acid molecule comprises the steps of: (a) contacting the polynucleotide or a complimentary nucleotide thereof and a reagent specifically hybridizing the polynucleotide under severe hybridization condition with a test sample including a nucleic acid molecule; and (b) detecting formation of a hybridized double strand.