| 摘要 |
A method of determining the location of an ingested capsule comprising the steps of providing an ingestible capsule having a pH sensor and a pressure sensor, having a subject ingest the capsule, recording pH measurements from the pH sensor as a function of time as the capsule moves through at least a portion of the gastrointestinal tract of the subject, recording pressure measurements from the pressure sensor as a function of time as the capsule moves through at least a portion of the gastrointestinal tract of the subject, deriving a pressure pattern as a function of time and the pressure measurements, providing a reference pH, analyzing the pH variations for the subject relative to the reference pH to determine the capsule's location at a first position, providing a reference pressure pattern, and analyzing the pressure pattern variations for the subject relative to the pressure pattern reference to determine the capsule's location at a second position. The pressure pattern may be frequency of contractions relative to a baseline over a given time interval or motility index. The method may further comprise the steps of analyzing the pressure pattern variations for the subject relative to the pressure pattern reference in determining the capsule's location at the first position and/or analyzing the pH variations for the subject relative to the pH reference in determining the capsule's location at the second position.
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