| 摘要 |
<p>Compositions and methods for producing monoclonal antibodies and their de rivatives reactive against bioactive lipid targets are described. These comp ositions include derivatized lipids, each of which comprises a bioactive lip id that having a polar head group and at least one hydrocarbon chain (e.g., a lysolipid such as lysophosphatidic acid or sphingosine-1 -phosphate) in wh ich a carbon atom has been derivatized with a pendant reactive group; immuno gens made by linking a derivatized lipid to a carrier moiety (e.g., a carrie r protein, polyethylene glycol, colloidal gold, alginate, or a silicone bead ); monoclonal antibodies and derivatives produced by immunizing an animal wi th such an immunogen; and therapeutic and diagnostic compositions containing such antibodies and antibody derivatives. Methods for making such derivatiz ed lipids, immunogens, and monoclonal antibodies and derivatives, methods fo r detecting such antibodies once generated, and therapeutic and diagnostic m ethods for using such antibodies and derivatives, are also described.</SDOAB ></p> |
