COMPOSITION FOR ANTI-INFLAMMATION

摘要

The present invention provides a composition for anti-inflammation comprising one or more ingredients of 8 -hydroxy guano sine (oh8G) and 8-hydroxydeoxyguanosine (oh8dG) as active ingredients. The present composition comprising one or more ingredients of oh8G and oh8dG suppresses the activity of Rac 2 of macrophage, thereby suppressing the activity of NADPH oxidase and also ROS production. Furthermore, the composition of the present invention suppresses the rising of blood concentration of pro-inflammatory cytokine induced by LPS, the increasing of MPO activity and Rac 2 activity, and the mortality of mouse due to LPS. Thus, the composition for anti-inflammation of the present invention can be used for treating various inflammatory diseases such as rheumatic arthritis, Lupus ethrythematosus, multiple scleroderma, adult respiratory distress syndrome (ARDS), etc., as an anti-inflammatory agent.