Small molecule antagonists of Bcl-2 family proteins

摘要

Disclosed is use of a gossypol compound selected from the group consisting of (±)-ethylgossypol, (-)-ethylgossypol, (+)-ethylgossypol, (±)- hemigossypolone, (-)-hemigossypolone, (+)-hemigossypolone, a Schiffs base of (±)- gossypol, a Schiffs base of (-)-gossypol, a Schiffs base of (+)-gossypol, a Schiffs base of (±)-gossypolone, a Schiffs base of (-)-gossypolone, a Schiffs base of (+)- gossypolone, a Schiffs base of (±)-gossypol acetic acid, a Schiffs base of (-)-gossypol acetic acid, a Schiffs base of (+)-gossypol acetic acid, a Schiffs base of (±)- ethylgossypol, a Schiffs base of (-)-ethylgossypol, a Schiffs base of (+)- ethylgossypol, a Schiffs base of(±)-hemigossypolone, a Schiffs base of(-)hemigossypolone, and a Schiffs base of (+)-hemigossypolone in the manufacture of a medicament for the treatment of cancer.