发明名称 |
PROCESS FOR PRODUCTION OF BIVALIRUDIN |
摘要 |
The invention relates to methods for the preparation of high purity Bivalirudin. The polypeptide is prepared in a high purity of at least 98.5% (by HPLC), wherein the total impurities amount to less than 1.5%, comprising not more than 0.5% [Asp<SUP>9</SUP>-Bivalirudin] and each is impurity less than 1.0%, and preferably having a purity of at least about 99.0% by HPLC, wherein the total impurities amount to less than 1.0%, comprising not more than 0.5% [Asp<SUP>9</SUP>-Bivalirudin] and each impurity is less than 0.5%. |
申请公布号 |
CA2618494(A1) |
申请公布日期 |
2007.03.22 |
申请号 |
CA20062618494 |
申请日期 |
2006.09.14 |
申请人 |
NOVETIDE, LTD. |
发明人 |
HAGI, ALON;BUTILCA, GABRIEL-MARCUS;IVCHENKO, ALEXANDER;BAR-OZ, LEAH;EIDELMAN, CHAIM;SHUSHAN, SHIMON;GADI, TEHILA;TOVI, AVI;ZAOUI, GIL |
分类号 |
C07K1/04;C07K14/815 |
主分类号 |
C07K1/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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