| 摘要 |
PROBLEM TO BE SOLVED: To provide an O-linked type sugar amino acid derivative having a new core 6 type structure for reconstructing various mucin type sugar chain structures and to provide a method for chemical synthesis of the derivative. SOLUTION: The O-linked type sugar amino acid derivative having the core 6 type structure is represented by structural formula (1) (wherein Bn represents a benzyl group; Ph represents a phenyl group; Ac represents an acetyl group; Fmoc represents a 9-fluorenylmethoxycarbonyl group; and R represents a hydrogen atom or a methyl group). In the O-linked type sugar amino acid derivative having the core 6 type structure, all the hydroxy groups in a galactose residue are protected with benzyl groups or benzylidene groups; all the hydroxy groups of an N-acetylglucosamine residue are protected with benzyl groups; the hydroxy group at the 3-position of an N-acetylgalactosamine residue is protected with a benzyl group and the amino group of a threonine residue or a serine residue is protected with an Fmoc. The method for synthesizing the derivative is provided. COPYRIGHT: (C)2007,JPO&INPIT
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