| 摘要 |
The invention is directed to a method of prophylactically or therapeutically treating an animal for an ocular-related disorder. The method comprises administering to an eye of the animal an expression vector comprising a nucleic acid sequence encoding an adenoviral-responsive gene product. The expression vector transduces a host cell and the nucleic acid sequence is expressed to produce the adenoviral-responsive gene product to treat prophylactically or therapeutically the ocular-related disorder. The invention also provides a method of reducing or inhibiting angiogenesis or photoreceptor cell loss in an eye. The method comprises administering to the eye an expression vector comprising a nucleic acid sequence encoding an adenoviral-responsive gene product. The expression vector transduces a host cell and the nucleic acid sequence is expressed to produce the adenoviral-responsive gene product thereby reducing or inhibiting angiogenesis or photoreceptor cell loss in the eye.
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