摘要 |
Methods and compositions for making nucleoside phosphoramidites and nucleic acids, including mono-, di-, and polynucleotides, comprising a linker covalently attached to a levulinyl moiety are provided. A levulinyl-protected linking moiety affords an orthogonal approach to modifying a polynucleotide during or after solid phase synthesis with a molecule of interest, for example, a conjugate or a dye. |
申请人 |
DHARMACON, INC.;HARTSEL, STEPHANIE, A.;KAISER, ROBERT, J.;DELANEY, MICHAEL, O. |
发明人 |
HARTSEL, STEPHANIE, A.;KAISER, ROBERT, J.;DELANEY, MICHAEL, O. |