| 摘要 |
The invention relates to the use of acylated 4-amidino- or 4-guanidinobenzylamine in accordance with the general formula I <?in-line-formulae description="In-line Formulae" end="lead"?>P4-P3-P2-P1 (I), <?in-line-formulae description="In-line Formulae" end="tail"?> where P4 is a monosubstituted or polysubstituted or unsubstituted benzylsulfonyl group, P3 is a monosubstituted or polysubstituted or unsubstituted, natural or unnatural alpha-amino acid or alpha-imino acid in the D configuration, P2 is a monosubstituted or polysubstituted or unsubstituted, natural or unnatural alpha-amino acid or alpha-imino acid in the L configuration, and P1 is a monosubstituted or polysubstituted or unsubstituted 4-amidino- or 4-guanidinobenzylamine group, for inhibiting plasma kallikrein (PK), factor XIa and factor XIIa, in particular for preventing the activation of coagulation at synthetic surfaces and for systemic administration as anticoagulants/-antithrombotic agents, in particular for preventing the activation of coagulation at synthetic surfaces for the purpose of averting thromboembolic events. |
