发明名称 |
TUMOR CYTOTOXICITY INDUCED BY MODULATORS OF THE CXCR4 RECEPTOR |
摘要 |
The present invention provides a means of selectively killing epithelial cell carcinomas by administering a CXCR4-specific sequence of the Gp120 protein or Nef proteins or the proteins themselves (the modulators) such as that found in strains HIV-1, HIV-2, SIV, or FIV CXCR4-specific Gp 120 sequences or Nef proteins or sequences may be delivered to the mucosa or systemically. The mucosal means of application include oral, intranasal, ocular, intravaginal, rectal, and/or intraurethral administration in liquid or particulate form. |
申请公布号 |
WO2004093782(A3) |
申请公布日期 |
2006.06.29 |
申请号 |
WO2003US08549 |
申请日期 |
2003.03.20 |
申请人 |
MOREHOUSE SCHOOL OF MEDICINE |
发明人 |
BOND, VINCENT, CRAIG;LILLARD, JAMES, M.;HUANG, JING, BO;BUMPERS, HARVEY;POWELL, MICHAEL |
分类号 |
A61K38/16;A61K;A61K9/00;C07K14/00;C07K14/155;C07K14/16 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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