发明名称 |
VIRULENT ONCOLYTIC HERPES SIMPLEX VIRUS STRAINS ENGINEERED TO COUNTER THE INNATE HOST RESPONSE |
摘要 |
The present invention relates to an avirulent, oncolytic herpes simplex virus modified from a wild-type herpes simplex virus so that both ?<SUB>1</SUB>34.5 genes of the virus have been deleted and each replaced with an interferon-resistance gene that is expressed as an immediate-early gene. The present invention also relates to a pharmaceutical composition that includes the modified herpes simplex virus of the present invention and a pharmaceutically acceptable vehicle for in situ administration to tumor cells. Also provided in the present invention are methods for killing tumor cells in a subject and for immunizing a subject against an infectious disease, cancer, or an autoimmune disease that involve administering to a subject the modified avirulent, oncolytic herpes simplex virus of the present invention. |
申请公布号 |
WO2006002394(A3) |
申请公布日期 |
2006.06.08 |
申请号 |
WO2005US22561 |
申请日期 |
2005.06.24 |
申请人 |
NEW YORK UNIVERSITY |
发明人 |
MOHR, IAN;MULVEY, MATTHEW |
分类号 |
C12N7/00;A61K35/00;A61K48/00;C12N15/63 |
主分类号 |
C12N7/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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