发明名称 |
CONTROLLED RELEASE FORMULATION FOR WATER SOLUBLE DRUGS IN WHICH A PASSAGEWAY IS FORMED IN SITU |
摘要 |
A controlled release pharmaceutical tablet is disclosed which is based on: (a) a compressed core which contains: i) a medicament; ii) from 5 to 20 % by weight of a water soluble osmotic agent based on the total weight of the compressed core; iii) a water soluble pharmaceutically acceptable polymeric binder; iv) a conventional pharmaceutical excipient; and (b) a dual layer membrane coating around said core which consists essentially of: i) a first inner coating layer for sustained release of the medicament, said inner coating layer consisting essentially of a plasticized water insoluble pharmaceutically acceptable polymer and a pharmaceutically acceptable water soluble polymer, and; ii) a second outer coating layer for immediate release of a medicament, said outer coating layer consisting essentially of an effective amount of a medicament and a water soluble polymer. The controlled release formulation is suitable for the once-a-day administration of medicaments.
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申请公布号 |
CA2217226(C) |
申请公布日期 |
2006.05.30 |
申请号 |
CA19962217226 |
申请日期 |
1996.03.13 |
申请人 |
ANDRX PHARMACEUTICALS, INC. |
发明人 |
CHEN, CHIH-MING;LEE, DER-YANG |
分类号 |
A61K9/22;A61K9/48;A61K9/00;A61K9/16;A61K9/24;A61K9/30;A61K9/36;A61K9/50;A61K9/52;A61K9/54;A61K9/56;A61K31/135;A61K31/137 |
主分类号 |
A61K9/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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