发明名称 |
5-AMINO-2,4,7-TRIOXO-3,4,7,8-TETRAHYDRO-2H-PYRIDO [2, 3-D] PYRIMIDINE DERIVATIVES AND RELATED COMPOUNDS |
摘要 |
The present invention relates to a pyrimidine compound represented by the following formula [I]: (see formula I) wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, and a pharmaceutical agent for the prophylaxis or treatment of a disease caused by undesirable cell proliferation, particularly an antitumor agent, which contains such compound. In certain aspects, the compound of the present invention has undesirable cell proliferation suppressing action, particularly, an antitumor action, and may be useful as an antitumor agent for the prophylaxis or treatment of cancer, antirheumatoid agent and the like. In addition, by the combined use with other antitumor agent such as alkylating agent, metabolism antagonist and the like, in certain aspects it can be an effective antitumor agent. |
申请公布号 |
CA2727841(A1) |
申请公布日期 |
2005.12.22 |
申请号 |
CA20052727841 |
申请日期 |
2005.06.10 |
申请人 |
JAPAN TOBACCO INC. |
发明人 |
KAWASAKI, HISASHI;ABE, HIROYUKI;HAYAKAWA, KAZUHIDE;IIDA, TETSUYA;KIKUCHI, SHINICHI;YAMAGUCHI, TAKAYUKI;NANAYAMA, TOYOMICHI;KURACHI, HIRONORI;TAMARU, MASAHIRO;HORI, YOSHIKAZU;TAKAHASHI, MITSURU;YOSHIDA, TAKAYUKI;SAKAI, TOSHIYUKI |
分类号 |
C07D471/04;A61K31/519;A61P35/00;C07C275/30;C07D239/545;C07D487/04 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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地址 |
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