| 摘要 |
PROBLEM TO BE SOLVED: To provide a medicine for inhibiting the release of elastase associated with ischemia reperfusion disorder observed in cerebral infarction, heart diseases, renal diseases, etc., and also inflammatory diseases such as chronic bronchitis, asthma, etc. SOLUTION: This elastase release inhibitor is a hydroxyaliphatic sulfonic acid analog expressed by the formula [wherein, X is ethylene, vinylene or ethynylene group; Y is ethylene, vinylene, ethynylene, OCH<SB>2</SB>or S(O)<SB>p</SB>CH<SB>2</SB>; (p) is 0, 1 or 2; (m) is 1 to 5 integer; (n) is 0 to 4 integer; R<SP>1</SP>is a 1-8C alkyl or the like; R<SP>2</SP>is H or methyl and the R<SP>1</SP>, R<SP>2</SP>bond each other to form a 3-8C cycloalkyl; R<SP>3</SP>is H or a 2-8C acyl; R<SP>4</SP>is OR<SP>5</SP>or NHR<SP>6</SP>; R<SP>5</SP>is H, a 1-4C alkyl, an alkali metal, an alkaline earth metal or ammonium; and R<SP>6</SP>is H or a 1-4C alkyl]. COPYRIGHT: (C)2005,JPO&NCIPI
|
