| 发明名称 |
2,4,DI (hetero-) arylamino (-oxy) -5-substituted pyrimidines as antineoplastic agents |
| 摘要 |
Pyrimidine derivatives of formula (I) wherein Q<SUB>1</SUB>, Q<SUB>2</SUB>, G and R<SUP>1 </SUP>are as defined within; and pharmaceutically acceptable salts and in vivo hydrolysable esters thereof are described. Processes for their manufacture, pharmaceutical compositions and their use as cyclin-dependent serine/threonine kinase (CDK) and focal adhesion kinase (FAK) inhibitors are also described.
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| 申请公布号 |
US2005090515(A1) |
申请公布日期 |
2005.04.28 |
| 申请号 |
US20040995931 |
申请日期 |
2004.11.24 |
| 申请人 |
ASTRAZENECA AB |
发明人 |
PEASE ELIZABETH J.;WILLIAMS EMMA J.;BRADBURY ROBERT H.;PEARSON STUART E. |
| 分类号 |
A61K31/505;A61K31/506;A61K31/5377;A61P35/00;A61P43/00;C07D239/48;C07D401/12;C07D403/12;C07D413/12;C07D453/02;C07D521/00;(IPC1-7):A61K31/513;C07D43/02 |
主分类号 |
A61K31/505 |
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