QUINAZOLINE DERIVATIVES AS MEDICAMENTS

摘要

Quinazoline derivatives have the formula (I) or the pharmaceutically acceptable salts thereof; wherein each of Z<5>, Z<6>, Z<7> and Z<8> is N or CH and wherein one or two Z<5>, Z<6>, Z<7> and Z<8> are N and wherein two adjacent Z positions cannot be N; wherein m and n are each independently 0-3; wherein R<1> is independently OH, SH, NH2, OR, SR, NHR, halo or R-halide; wherein two adjacent R<1> groups may be joined to form an aliphatic hetero cycle ring of 5-6 members; wherein R<2> is independently R, halo, R-halide, OR-halide, NH2, CONH2 or CONHR; wherein R is optionally substituted C1-C12 alkyl, C1-C12 alkenyl, C1-C12 alkynyl, or aryl C1-C12 alkyl, containing 0-4 heteroatoms in place of a carbon in the carbon backbone, where the optional substituents are =O, =N, or OH; and wherein R<3> is H or CH3. Such compounds are useful in pharmaceutical compositions and methods of treating conditions characterized by enhanced TGFbeta activity.