SURFACES THAT SELECTIVELY BIND TO MOIETIES

摘要

A thin film made of a stiff polymer and having indentations on its surface, and methods of making using the thin film are disclosed. The surface includes a plurality of indentations, the shape of each indentation corresponding to an outer surface of and imprint moiety, such as and animal, bacterial, or plant cell. The thin film can be mounted on a detector, which can be used to selectively bind to and detect the imprint moiety in a sample, e.g., a biological or environmental sample, at a minimum concentration of as low as 500 to 1000 imprint moieties per milliliter of sample.